Campbell R J, Ilett K F, Dusci L
Anaesth Intensive Care. 1986 Nov;14(4):343-6. doi: 10.1177/0310057X8601400402.
Venous plasma concentrations of bupivacaine were measured in children following axillary brachial plexus block with either 2 mg/kg (n = 21) or 3 mg/kg (n = 20) of bupivacaine. Absorption was very rapid with a mean time to peak concentrations of 0.37 hours for both doses. Mean peak plasma concentration was 1.35 mg/l after the 2 mg/kg dose and 1.84 mg/kg after the 3 mg/kg dose. Even after a 30% allowance for anticipated higher arterial concentrations, the plasma levels found in the present study were well below those at which toxicity is considered likely (greater than 4 mg/l).
对接受2mg/kg（n = 21）或3mg/kg（n = 20）布比卡因腋路臂丛神经阻滞的儿童测量了布比卡因的静脉血浆浓度。两种剂量的吸收都非常迅速，达到峰值浓度的平均时间均为0.37小时。2mg/kg剂量后平均血浆峰值浓度为1.35mg/l，3mg/kg剂量后为1.84mg/kg。即使在考虑到预期更高的动脉浓度而增加30%的余量后，本研究中发现的血浆水平仍远低于被认为可能出现毒性的水平（大于4mg/l）。
