Duan Xiaoxia, Sun Rui, Tang Juan, Li Shun, Yang Xiao, Zheng Xueli, Li Ruixiang, Chen Hua, Fu Haiyan, Yuan Maolin
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
J Org Chem. 2022 Jun 17;87(12):7975-7988. doi: 10.1021/acs.joc.2c00614. Epub 2022 Jun 5.
Nucleophilic recyclization of pyridinium salts involving a CCN interchange ring transformation for the synthesis of 2-methylnicotinonitrile derivatives was herein developed. 3-Aminocrotononitrile produced from CHCN acted as a C-nucleophile, as well as the source of CH and CN groups, which was supported by isotope-labeling and control experiments.
本文开发了一种涉及CCN交换环转化的吡啶盐亲核环化反应，用于合成2-甲基烟腈衍生物。由CHCN生成的3-氨基巴豆腈作为C-亲核试剂，同时也是CH和CN基团的来源，这一点得到了同位素标记和对照实验的支持。
