吡啶向芳基二醛的骨架编辑。
Skeletal editing of pyridines to aryldialdehydes.
作者信息
Yan Meixin, Shi Yonglin, Lv Cong, Huang Shunyao, Li Shun, Yang Dexi, Zhao Jiangui, Su Zhishan, Jiang Weidong, Xue Weichao, Xu Jiaqi, Zheng Xueli, Li Ruixiang, Chen Hua, Fu Haiyan
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan, PR China.
College of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, PR China.
出版信息
Nat Commun. 2025 Aug 4;16(1):7133. doi: 10.1038/s41467-025-62627-8.
Electron-deficient nitrogen-containing aromatic heterocycles, particularly pyridine derivatives, can be converted into all-carbon aromatic frameworks via the ANRORC (Addition of Nucleophile, Ring-Opening, and Ring-Closing) skeletal editing process, providing a convenient tool for molecular diversification. However, reported methods are mainly limited to nucleophilic modification of ring-opening species. Herein, we report a distinct electrophilic modification method, smoothly converting pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.
缺电子含氮芳香杂环，特别是吡啶衍生物，可通过亲核试剂加成、开环和闭环（ANRORC）骨架编辑过程转化为全碳芳香骨架，为分子多样化提供了一种便捷工具。然而，已报道的方法主要限于开环物种的亲核修饰。在此，我们报道了一种独特的亲电修饰方法，可将吡啶顺利转化为芳烃-1,3-二醛或萘-1,3-二醛。
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