Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Cancer Prevention Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Nutr Cancer. 2022;74(10):3457-3467. doi: 10.1080/01635581.2022.2084557. Epub 2022 Jun 6.
We performed a meta-analysis to investigate the association between pretreatment body mass index (BMI) and prognosis of nasopharyngeal carcinoma (NPC). Case-control and cohort studies were searched from PubMed, Web of Science, EMBASE, and CNKI databases. Pooled hazard ratios (HR) with 95% confidence intervals (CI) for overall survival (OS) or distant metastasis-free survival (DMSF) were used to estimate the prognostic value. Bias in the included studies was evaluated using funnel plots. The results showed that compared with normal weight patients, the estimated HR of OS was 1.54 (95% CI: 1.25-1.90; < 0.05) for underweight, 0.63 (95% CI: 0.48-0.83; < 0.05) for overweight, and 0.67 (95% CI: 0.41-1.08; = 0.102) obese patients. We also found that compared with normal-weight patients, the estimated HR of DMFS was 1.63 (95% CI: 1.38-1.92; < 0.05) for underweight, 0.83 (95% CI: 0.61-1.13; = 0.244) for overweight, and 0.60 (95% CI: 0.39-0.92; < 0.05) for patients with obesity. BMI is an independent prognostic factor for NPC survival. Being underweight before treatment was associated with poorer OS and DMFS in patients with NPC. Neither overweight nor obesity before treatment has an unfavorable effect on NPC survival.
我们进行了一项荟萃分析，以研究治疗前体重指数（BMI）与鼻咽癌（NPC）预后之间的关系。从 PubMed、Web of Science、EMBASE 和 CNKI 数据库中搜索了病例对照和队列研究。使用合并的风险比（HR）及其 95%置信区间（CI）来估计总生存率（OS）或远处无转移生存率（DMSF），以评估预后价值。使用漏斗图评估纳入研究中的偏倚。结果表明，与体重正常的患者相比，体重过轻、超重和肥胖患者的 OS 估计 HR 分别为 1.54（95%CI：1.25-1.90；<0.05）、0.63（95%CI：0.48-0.83；<0.05）和 0.67（95%CI：0.41-1.08；=0.102）。我们还发现，与体重正常的患者相比，体重过轻、超重和肥胖患者的 DMSF 估计 HR 分别为 1.63（95%CI：1.38-1.92；<0.05）、0.83（95%CI：0.61-1.13；=0.244）和 0.60（95%CI：0.39-0.92；<0.05）。BMI 是 NPC 生存的独立预后因素。治疗前体重过轻与 NPC 患者的 OS 和 DMSF 较差相关。治疗前超重或肥胖均不会对 NPC 生存产生不利影响。
