昼夜节律调节的神经生物学。

Neurobiology of Circadian Rhythm Regulation.

机构信息

Department of Psychology, School of Biology and Ecology, Graduate School of Biomedical Science and Engineering, University of Maine, 5742 Little Hall, Orono, ME 04467, USA.

Department of Neurobiology, Center for Sleep and Circadian Biology, Northwestern University, 2205 Tech Drive, Hogan Hall 2-160, Evanston, IL 60208, USA.

出版信息

Sleep Med Clin. 2022 Jun;17(2):141-150. doi: 10.1016/j.jsmc.2022.02.006. Epub 2022 Apr 22.

DOI:10.1016/j.jsmc.2022.02.006

PMID:35659069

Abstract

In this review, we provide a summary of the field of mammalian circadian neurobiology circa 2015. While many additional details have emerged in the intervening 7 years, understanding of the fundamental structure and function of this critical neural system remains intact. Thus, the present review continues to provide a valuable introduction for those seeking an integrative multilevel overview of the circadian system. In brief, the circadian system comprises a coupled network of molecular/cellular- and tissue-level oscillators, hierarchically coordinated by the hypothalamic suprachiasmatic nuclear circadian pacemaker, and entrained by both photic and nonphotic signals.

摘要

在这篇综述中，我们提供了一个关于哺乳动物生物钟神经生物学的概述，截止到 2015 年。虽然在这 7 年中出现了许多其他的细节，但对这个关键神经系统的基本结构和功能的理解仍然没有改变。因此，本综述继续为那些寻求对生物钟系统进行综合多层次概述的人提供有价值的介绍。简而言之，生物钟系统由分子/细胞和组织水平振荡器的耦合网络组成，由下丘脑视交叉上核的生物钟起搏器进行层次协调，并由光信号和非光信号进行同步。