Division of Neonatology, Department of Pediatrics, UT Health San Antonio, 7703 Floyd Curl, San Antonio, TX 78229, USA; Neonatology Services, University Health System, 4502 Medical Dr, San Antonio, TX, 78229, USA.
Division of Neonatology, Department of Pediatrics, UT Health San Antonio, 7703 Floyd Curl, San Antonio, TX 78229, USA.
Clin Perinatol. 2022 Jun;49(2):393-404. doi: 10.1016/j.clp.2022.02.003. Epub 2022 Apr 21.
Hypoglycemia is a common condition in the newborn period. Several intrinsic and extrinsic factors play a role in the degree/duration of hypoglycemia. Multiple thresholds have been proposed as a potential point whereby hypoglycemia may have short and long-term adverse effects. Rather than a "numerical" threshold, treatment approaches should be individualized and tailored to the etiology, symptoms, and neonatal underlying conditions. Hyperglycemia in the newborn period is commonly seen in preterm infants and can exert gluco-toxic effects in organs at critical periods of development. Considering the peripheral insulin resistance (IR) of prematurity and contributing factors is key to achieving euglycemia.
低血糖是新生儿期的一种常见病症。一些内在和外在的因素会影响低血糖的程度/持续时间。已经提出了多个阈值作为可能的点，低血糖可能会对新生儿产生短期和长期的不良影响。治疗方法不应是一个“数值”阈值，而应该根据病因、症状和新生儿的潜在情况进行个体化和定制。早产儿中常见高血糖，并且在器官发育的关键时期会产生糖毒性作用。考虑到早产儿的外周胰岛素抵抗（IR）和相关因素是实现血糖正常的关键。
