头围在生命早期的遗传学及其与神经、精神和认知结果的遗传相关性。
Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.
机构信息
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
出版信息
BMC Med Genomics. 2022 Jun 4;15(1):124. doi: 10.1186/s12920-022-01281-1.
BACKGROUND
Head circumference is associated with intelligence and tracks from childhood into adulthood.
METHODS
We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.
RESULTS
Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.
CONCLUSIONS
The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
背景
头围与智力有关，并从儿童期一直跟踪到成年期。
方法
我们对 29192 名 6 至 30 个月大的参与者进行了全基因组关联研究的荟萃分析和头围随访。
结果
在总共 29192 名 6 至 30 个月大的参与者中，共有 7 个位点在联合发现和复制分析中达到了全基因组显著水平，其中三个位于 ARFGEF2、MYCL1 和 TOP1 附近的位点是新的。我们观察到，早期头围与成人颅内体积、受教育年限、儿童和成人智力呈正遗传相关，但与成人精神、神经或与人格相关的表型无关。
结论
本研究结果表明，儿童早期头围和成人头围的生物学过程有很大的重叠。儿童早期头围与整个生命周期认知结果的关联在一定程度上可以用遗传来解释。
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