Digestive Endoscopy and Gastroenterology Unit, SS Annunziata Hospital, ASL2 Abruzzo, Chieti, Italy.
Digestive Endoscopy and Gastroenterology Unit, SS Annunziata Hospital, ASL2 Abruzzo, Chieti, Italy; Department of Medicine and Ageing Sciences and Center for Advanced Studies and Technology (C.A.S.T.), University "G. D'Annunzio", Chieti-Pescara, Chieti, Italy.
Clin Res Hepatol Gastroenterol. 2022 Aug-Sep;46(7):101954. doi: 10.1016/j.clinre.2022.101954. Epub 2022 Jun 2.
Zinc L-carnosine is a pharmaceutical compound with direct mucosal cytoprotective and anti-inflammatory action through its antioxidative effects, cytokine modulation and membrane-stabilizing properties. Chemically, it is not an anti-secretory, antacid or raft-forming agent; its properties are mainly mediated by its higher affinity for damaged mucosa that permits the release of zinc locally by ligand exchange. Beneficial effects on various types of mucosal damage have been described in vitro and in vivo, in both animals and humans. It has been shown to promote repair of mucosal injury in human studies and has been widely used for the treatment of peptic ulcers, chemoradiotherapy-induced oral mucositis and esophagitis. More recently, the therapeutic applications of Zinc L-carnosine have been extended to the prevention and cure of various types of intestinal damage, including ulcerative colitis, iatrogenic ulcers after operative endoscopy, hemorrhoidal disease and impaired intestinal permeability. This review concentrates mainly on the current and future applications of zinc L-carnosine in gastrointestinal disease, and may be of use to gastroenterologists and endoscopists. It describes the therapeutic principles and benefits of this interesting molecule and discusses the potential future fields of interest for clinical use in humans.
锌-L-肉碱是一种药物化合物，通过其抗氧化作用、细胞因子调节和膜稳定特性，具有直接的黏膜细胞保护和抗炎作用。从化学上讲，它不是一种抗分泌、抗酸或筏形成剂;其特性主要是通过其与受损黏膜的更高亲和力来介导的，这种亲和力允许通过配体交换局部释放锌。在体外和体内，在动物和人类中，已经描述了它对各种类型的黏膜损伤的有益作用。它已被证明能促进人类研究中黏膜损伤的修复，并已被广泛用于治疗消化性溃疡、化疗和放疗引起的口腔黏膜炎和食管炎。最近，锌-L-肉碱的治疗应用已经扩展到预防和治疗各种类型的肠道损伤，包括溃疡性结肠炎、内镜手术后的医源性溃疡、痔疮和肠道通透性受损。这篇综述主要集中在锌-L-肉碱在胃肠道疾病中的当前和未来应用，可能对胃肠病学家和内镜医生有用。它描述了这种有趣分子的治疗原则和益处，并讨论了其在人类临床应用中未来可能感兴趣的领域。
