Riely C A, Latham P S, Romero R, Duffy T P
Ann Intern Med. 1987 May;106(5):703-6. doi: 10.7326/0003-4819-106-5-703.
Acute fatty liver of pregnancy was diagnosed in nine patients over a 10-year period. Eight patients had severe hepatic dysfunction typical for this syndrome and one had subclinical disease but typical hepatic histologic findings. All patients survived with little fetal wastage; all had preeclampsia. Histologic findings included cholestasis, hepatocellular necrosis, and inflammation, as well as microvesicular fat. Histologic findings from biopsy specimens of four of seven patients were initially misinterpreted as hepatitis. This disorder may have both a broad clinical and histologic spectrum; it is probably not rare but often misdiagnosed, perhaps as viral hepatitis. The concurrence of this disorder with toxemia of pregnancy suggests that these entities may be pathophysiologically related.
在10年期间，9名患者被诊断为妊娠急性脂肪肝。8名患者出现了该综合征典型的严重肝功能障碍，1名患者有亚临床疾病但有典型的肝脏组织学表现。所有患者均存活，胎儿损失很少；所有患者都患有先兆子痫。组织学表现包括胆汁淤积、肝细胞坏死、炎症以及微泡脂肪。7名患者中4名的活检标本组织学表现最初被误诊为肝炎。这种疾病可能具有广泛的临床和组织学谱；它可能并不罕见，但常被误诊，可能被误诊为病毒性肝炎。这种疾病与妊娠中毒症同时出现表明这些病症在病理生理上可能相关。
