Miller M A, Mark G J, Kanarek D
Am J Med. 1978 Aug;65(2):373-8. doi: 10.1016/0002-9343(78)90835-5.
Multiple peripheral carcinoid tumors were found on lung biopsy in a 53 year old woman with an eight year history of pulmonary nodules. The biopsy specimen showed nodules varying from 1 to 7 mm in greatest diameter. The larger lesions were typical bronchial carcinoids whereas the smaller ones resembled pulmonary "tumorlets." Electron microscopy showed neurosecretory granules typical of carcinoids. The common multicentric origin of carcinoids and tumorlets from Kulchitsky cells is discussed. Pulmonary function testing revealed mild obstructive and restrictive defects, both attributed to the carcinoid tumors. The history, pathology and physiology of this unusual case are presented in detail, with a review of the literature. Obstructive airways disease, presumably due to the extensive bronchiolar involvement, has not previously been reported in this entity.
一名有8年肺结节病史的53岁女性在肺活检时发现多个外周类癌肿瘤。活检标本显示结节最大直径在1至7毫米之间不等。较大的病变为典型的支气管类癌，而较小的病变类似肺“微瘤”。电子显微镜检查显示出类癌典型的神经分泌颗粒。讨论了类癌和微瘤源自库尔契茨基细胞的常见多中心起源。肺功能测试显示轻度阻塞性和限制性缺陷，均归因于类癌肿瘤。本文详细介绍了这一罕见病例的病史、病理和生理学，并对文献进行了综述。此前该疾病实体中尚未有因广泛细支气管受累导致阻塞性气道疾病的报道。
