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多灶性微小结节和微类癌瘤引起的闭塞性细支气管炎经单肺移植成功治愈。

Obliterative bronchiolitis caused by multiple tumourlets and microcarcinoids successfully treated by single lung transplantation.

作者信息

Sheerin N, Harrison N K, Sheppard M N, Hansell D M, Yacoub M, Clark T J

机构信息

Department of Thoracic Medicine, Royal Brompton National Heart and Lung Hospital, London, UK.

出版信息

Thorax. 1995 Feb;50(2):207-9. doi: 10.1136/thx.50.2.207.

DOI:10.1136/thx.50.2.207
PMID:7701466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473927/
Abstract

Histological examination of a lung removed at transplantation revealed multiple peripheral tumourlets and microcarcinoids in close association with bronchioles causing an obliterative bronchiolitis. This was an unexpected finding but explained the progressive airflow limitation which characterised the patient's clinical course.

摘要

对移植时切除的肺进行组织学检查发现，多个外周微瘤和微类癌与细支气管紧密相连，导致细支气管闭塞性炎症。这是一个意外发现，但解释了以患者临床病程为特征的进行性气流受限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac5/473927/cdebbb401a35/thorax00307-0110-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac5/473927/6c1276adc46a/thorax00307-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac5/473927/cdebbb401a35/thorax00307-0110-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac5/473927/6c1276adc46a/thorax00307-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ac5/473927/cdebbb401a35/thorax00307-0110-b.jpg

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本文引用的文献

1
Tumourlets of the lung.肺的微小瘤
J Pathol Bacteriol. 1955 Oct;70(2):529-41. doi: 10.1002/path.1700700231.
2
Neuroendocrine components of the bronchopulmonary tract: hyperplasias, dysplasias, and neoplasms.支气管肺组织的神经内分泌成分：增生、发育异常及肿瘤
Lab Invest. 1983 Nov;49(5):519-37.
3
Carcinoid tumours of the bronchus: a 33 year experience.支气管类癌肿瘤：33年的经验
肺纤维化的挑战。2：细支气管周围纤维化。
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4
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Thorax. 2007 Mar;62(3):248-52. doi: 10.1136/thx.2006.063065. Epub 2006 Nov 10.
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4
Carcinoid tumorlets of the lung with metastasis to a peribronchial lymph node. Report of a case and review of the literature.肺类癌瘤转移至支气管周围淋巴结。1例报告并文献复习。
Cancer. 1985 May 15;55(10):2472-6. doi: 10.1002/1097-0142(19850515)55:10<2472::aid-cncr2820551027>3.0.co;2-y.
5
Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease.简短报告：特发性肺神经内分泌细胞弥漫性增生与气道疾病
N Engl J Med. 1992 Oct 29;327(18):1285-8. doi: 10.1056/NEJM199210293271806.
6
Carcinoid lung: diffuse pulmonary infiltration by a multifocal bronchial carcinoid.类癌性肺：多灶性支气管类癌引起的弥漫性肺浸润。
Thorax. 1976 Apr;31(2):212-9. doi: 10.1136/thx.31.2.212.
7
Multiple peripheral pulmonary carcinoids and tumorlets of carcinoid type, with restrictive and obstructive lung disease.多发外周型肺类癌及类癌型微瘤，伴限制性和阻塞性肺病。
Am J Med. 1978 Aug;65(2):373-8. doi: 10.1016/0002-9343(78)90835-5.
8
Peripheral pulmonary carcinoid tumors.周围型肺类癌肿瘤
Cancer. 1976 Apr;37(4):1977-98. doi: 10.1002/1097-0142(197604)37:4<1977::aid-cncr2820370450>3.0.co;2-4.
9
Pulmonary tumorlet. A form of peripheral carcinoid.肺微小瘤。一种周围型类癌。
Cancer. 1976 Mar;37(3):1469-77. doi: 10.1002/1097-0142(197603)37:3<1469::aid-cncr2820370332>3.0.co;2-h.