Remacle M, Marbaix E, Bertrand B, Hamoir M
Ann Otolaryngol Chir Cervicofac. 1987;104(1):37-43.
Results of treatment of patulous glottis by injection of collagen are discussed. The technique used differs little from that in which Teflon is employed, the difference being that the collagen paste is injected into Reinke's space. The quantity deposited varies between 1 and 1.5 cm3. Twenty-five patients had been treated in this way by April 1986, the longest follow up being for 19 months (mean: 9.5 months). The compound presents remarkable tolerance and no complication has been noted up to the present. Results were at least equal to those obtained using Teflon. Vocal quality was evaluated, apart from by vocal recordings, by analysis of vocal spectrum and objective measurements such as phonatory quotient and output. Results appear to be stable and although some reduction in quantity injected was noted most of the collagen becomes living tissue by colonization with host tissue. Availability of new generations of collagen such as that crosslinked at 35 mg/ml will probably resolve definitely the problem of persistence of results.
本文讨论了通过注射胶原蛋白治疗声门张开的结果。所采用的技术与使用特氟龙的技术差别不大，不同之处在于将胶原蛋白糊剂注入Reinke间隙。注入的量在1至1.5立方厘米之间。截至1986年4月，已有25例患者接受了这种治疗，最长随访时间为19个月（平均：9.5个月）。该化合物具有显著的耐受性，目前尚未发现并发症。结果至少与使用特氟龙时相同。除了通过声带录音外，还通过分析声谱以及诸如发声商和输出等客观测量来评估音质。结果似乎是稳定的，尽管注意到注入量有所减少，但大多数胶原蛋白通过宿主组织的定植变成了活组织。新一代胶原蛋白（如35毫克/毫升交联的胶原蛋白）的可得性可能会彻底解决结果持久性的问题。
