Remacle M, Marbaix E
Department of ENT, University Hospital of Mont-Godinne, Louvain University, Yvoir, Belgium.
Arch Otorhinolaryngol. 1988;245(4):203-9. doi: 10.1007/BF00463928.
We have studied two postmortem human laryngeal specimens after the injection of collagen. The first larynx was removed 14 days after injection, while the second was examined 5 months after injection. The specimens are described macroscopically and microscopically. Excellent tolerance to the collagen was noted, with virtually no inflammatory reaction seen. The collagen injected seems to have been colonized progressively by the host cells and by neovessels. These findings coincide closely with those observed in animal models. In comparison to the inflammatory granulomas found after injections with Teflon, the absence of inflammatory reactions following the use of collagen does at least contribute to justifying its continued application clinically.
我们研究了注射胶原蛋白后的两份人类喉部尸检标本。第一个喉部在注射后14天被切除，而第二个在注射后5个月进行检查。对标本进行了宏观和微观描述。观察到对胶原蛋白具有极佳的耐受性，几乎未见炎症反应。注入的胶原蛋白似乎已逐渐被宿主细胞和新生血管占据。这些发现与在动物模型中观察到的结果密切相符。与注射特氟龙后发现的炎性肉芽肿相比，使用胶原蛋白后无炎症反应这一点至少有助于说明其在临床上持续应用的合理性。
