Giebink G S, Ripley M L, Wright P F
Ann Otol Rhinol Laryngol. 1987 Mar-Apr;96(2 Pt 1):199-206. doi: 10.1177/000348948709600212.
The eustachian tubes of 29 influenza A virus-infected chinchillas were examined for histopathologic signs at intervals up to 21 days after inoculation to elucidate the pathologic basis of negative middle ear pressure, which occurs during viral respiratory tract infection in humans. In the animal model, eardrum inflammation and negative middle ear pressure mirrored epithelial damage in the eustachian tube and the accumulation of cellular and mucous debris in the tubal lumen. Epithelial damage was greatest in the proximal two thirds of the tube near the nasopharynx, whereas goblet cell metaplasia and increased secretory activity was greatest in the distal, tympanic one third of the tube. These results provide a morphologic correlate to the development of negative middle ear pressure, and perhaps explain the pathologic basis for purulent otitis media during viral respiratory tract infection.
对29只感染甲型流感病毒的栗鼠的咽鼓管进行检查，在接种后长达21天的时间间隔内观察组织病理学迹象，以阐明人类病毒性呼吸道感染期间出现的中耳负压的病理基础。在该动物模型中，鼓膜炎症和中耳负压反映了咽鼓管上皮损伤以及管腔内细胞和粘液碎片的积聚。上皮损伤在靠近鼻咽的咽鼓管近端三分之二处最为严重，而杯状细胞化生和分泌活动增加在咽鼓管远端、鼓室三分之一处最为明显。这些结果为中耳负压的发展提供了形态学关联，或许也解释了病毒性呼吸道感染期间化脓性中耳炎的病理基础。
