Graduate Program in Life Sciences, Molecular Microbiology and Immunology Program, University of Maryland—Baltimore, Baltimore, Maryland, USA.
Clin Microbiol Rev. 2012 Jan;25(1):193-213. doi: 10.1128/CMR.00013-11.
Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or within the human body, often as multifaceted polymicrobial biofilm communities at mucosal sites and on abiotic surfaces. Only recently have we begun to appreciate the complicated biofilm phenotype during infection; moreover, even less is known about the interactions that occur between microorganisms during polymicrobial growth and their implications in human disease. Therefore, this review focuses on polymicrobial biofilm-mediated infections and examines the contribution of bacterial-bacterial, bacterial-fungal, and bacterial-viral interactions during human infection and potential strategies for protection against such diseases.
微生物在人体表面或内部与细菌、真菌、古菌和病毒共同存在，通常在黏膜部位和非生物表面形成多层面的微生物混合生物膜群落。直到最近，我们才开始了解感染过程中的复杂生物膜表型；此外，对于微生物在混合生长过程中发生的相互作用及其在人类疾病中的意义，我们知之甚少。因此，本综述重点关注混合微生物生物膜介导的感染，并研究了细菌-细菌、细菌-真菌和细菌-病毒相互作用在人类感染中的贡献以及针对此类疾病的潜在保护策略。
