Thomas J, Thomas E, Taboury J A, Taillandier E, Boccon-Gibod L, Steg A
Ann Urol (Paris). 1987;21(1):37-41.
A series of cystine stones extracted from the same subject by pyelotomy was used to study the in vitro solubility of these stones in various solutions. Isotonic bicarbonated saline presented a definite dissolving action, but the stone dissolved relatively slowly alpha-mercapto-propionyl-glycine was much more active, even when mixed urine. N-acetylcystine had the same degree of effectiveness as alpha-mercapto-propionyl-glycine. One stone in this series, which was partially covered by a coating of calcium phosphate, dissolved much more slowly than the other stones. In subjects with cystine stones, longstanding large stones are frequently mixtures of phosphates and cystine and, in 21 cases, chemical analyses and infra-red spectrography demonstrated the presence of calcium phosphate on the surface or in the inferior of these stones, associated with ammoniaco-magnesium phosphate in three cases. The presence of phosphates makes oral medical treatment ineffective, but mixed stones are more friable than pure cystine stones and are therefore easier to treat by extracorporeal lithotripsy.
通过肾盂切开术从同一受试者身上取出的一系列胱氨酸结石用于研究这些结石在各种溶液中的体外溶解度。等渗碳酸氢盐盐水呈现出一定的溶解作用，但结石溶解相对较慢。α-巯基丙酰甘氨酸活性更强，即使在混合尿液中也是如此。N-乙酰胱氨酸与α-巯基丙酰甘氨酸具有相同程度的有效性。该系列中的一块结石部分被磷酸钙涂层覆盖，其溶解速度比其他结石慢得多。在患有胱氨酸结石的受试者中，长期存在的大结石通常是磷酸盐和胱氨酸的混合物，在21例病例中，化学分析和红外光谱显示这些结石表面或内部存在磷酸钙，其中3例与磷酸氨镁有关。磷酸盐的存在使口服药物治疗无效，但混合结石比纯胱氨酸结石更易碎，因此更容易通过体外碎石术治疗。
