Lysenkova L N, Brazhnikova M G, Borisova V N, Aleksandrova L G, Rubasheva L M
Antibiot Med Biotekhnol. 1986 Dec;31(12):897-9.
Octamycin, an original polyenic antibiotic was developed. The antibiotic is of an amphoteric character. The number and nature of the functional groups were determined by potentiometric titration. It was shown that the antibiotic contained the neutral sugar galactose. The equivalent weight of the antibiotic (990) was measured by potentiometric titration and the content of the sugar in the molecule. With high performance liquid chromatography it was demonstrated that the antibiotic consisted of 2 components at a ratio of 1:2. The molecular weights of the components were evaluated with mass spectrometry.
开发了一种原始的多烯抗生素八霉素。该抗生素具有两性特征。通过电位滴定法确定了官能团的数量和性质。结果表明该抗生素含有中性糖半乳糖。通过电位滴定法和分子中糖的含量测定了抗生素的当量（990）。高效液相色谱法表明该抗生素由两种比例为1:2的组分组成。用质谱法评估了各组分的分子量。
