甲硝唑和替硝唑对艰难梭菌和厌氧消化链球菌的比较活性
Comparative activity of metronidazole and tinidazole against Clostridium difficile and Peptostreptococcus anaerobius.
作者信息
Jokipii A M, Jokipii L
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):183-6. doi: 10.1128/AAC.31.2.183.
Abstract
Broth dilution MICs of metronidazole against 38 strains of Clostridium difficile (0.13 microgram/ml) and 11 strains of Peptostreptococcus anaerobius (0.11 microgram/ml) were lower than those of tinidazole (0.16 and 0.17 microgram/ml, respectively). As molar concentrations the nitroimidazoles were equally active. The MICs of the two drugs correlated positively, and the relative activity of tinidazole increased with decreasing susceptibility of both species.
摘要
甲硝唑对38株艰难梭菌的肉汤稀释最低抑菌浓度（0.13微克/毫升）和对11株厌氧消化链球菌的肉汤稀释最低抑菌浓度（0.11微克/毫升）低于替硝唑（分别为0.16和0.17微克/毫升）。以摩尔浓度计，硝基咪唑类药物具有同等活性。两种药物的最低抑菌浓度呈正相关，且替硝唑的相对活性随两种菌敏感性降低而增加。
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