Hu Lihua, Bai Yi, Hu Guiping, Zhang Yan, Han Xiaoning, Li Jianping
Department of Cardiology, Peking University First Hospital, Beijing, China.
Department of Epidemiology and Bio-Statistics, School of Public Health, Peking University, Beijing, China.
Front Nutr. 2022 May 19;9:840804. doi: 10.3389/fnut.2022.840804. eCollection 2022.
Magnesium supplementation may extend the life span; however, the biological mechanism is still unknown. Leukocyte telomere length (LTL) is a marker of cell aging and biological health in humans. Data concerning whether magnesium supplementation can maintain telomere length, thus prolonging life are limited. We aimed to investigate the association between dietary magnesium intake and LTL in United States middle-aged and elderly adults.
A total of 4,039 United States adults aged ≥ 45 years from National Health and Nutrition Examination Survey (1999-2002). Dietary magnesium intake was collected by a trained interviewer using 24-h dietary recall method and LTL was obtained using the quantitative polymerase chain reaction method. Multiple linear regression analysis was performed to evaluate the crude and adjusted association of dietary magnesium intake with LTL.
The overall mean (SD) of LTL was 5.6 (0.6) kp. After adjusting potential confounders, every 1 mg increase in log-transformed dietary magnesium intake was associated with 0.20 kp (95% confidence intervals: 0.05-0.34) longer LTL. Participants with the highest tertile (≥299 mg) of dietary magnesium intake had statistically significant longer LTL (β = 0.07, = 0.038) compared with the lowest tertile (<198 mg), with significant linear trends across tertiles. Moreover, the association between dietary magnesium intake and LTL was significantly stronger in participants with higher levels of education (≥high school compared with < high school, for interaction = 0.002). -value analysis suggested robustness to unmeasured confounding.
Our findings showed that increased dietary magnesium intake was associated with longer LTL, which suggested that magnesium was conducive to a longer life expectancy.
补充镁可能会延长寿命；然而，其生物学机制仍不清楚。白细胞端粒长度（LTL）是人类细胞衰老和生物健康的一个标志物。关于补充镁是否能维持端粒长度从而延长寿命的数据有限。我们旨在研究美国中老年成年人饮食中镁摄入量与LTL之间的关联。
共有4039名年龄≥45岁的美国成年人参与了国家健康与营养检查调查（1999 - 2002年）。饮食中镁的摄入量由经过培训的访谈员采用24小时饮食回顾法收集，LTL则使用定量聚合酶链反应法获得。进行多元线性回归分析以评估饮食中镁摄入量与LTL之间的原始关联和校正关联。
LTL的总体平均值（标准差）为5.6（0.6）千碱基对。在调整潜在混杂因素后，对数转换后的饮食镁摄入量每增加1毫克，与LTL延长0.20千碱基对（95%置信区间：0.05 - 0.34）相关。饮食镁摄入量处于最高三分位数（≥299毫克）的参与者与最低三分位数（<198毫克）相比，LTL在统计学上显著更长（β = 0.07，P = 0.038），且三分位数之间存在显著的线性趋势。此外，在受教育程度较高的参与者中（≥高中与<高中相比，交互作用的P值 = 0.002），饮食镁摄入量与LTL之间的关联显著更强。P值分析表明对未测量的混杂因素具有稳健性。
我们的研究结果表明，饮食中镁摄入量增加与更长的LTL相关，这表明镁有助于延长预期寿命。
