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免疫性血小板减少症的4T原则:量身定制治疗血小板减少症的疗法

The 4 T's of ITP: Tailoring Therapies to Treat Thrombocytopenia.

作者信息

Hughes David

机构信息

Boston University School of Medicine, Boston, Massachusetts.

出版信息

J Adv Pract Oncol. 2022 Apr;13(3):337-340. doi: 10.6004/jadpro.2022.13.3.32. Epub 2022 May 23.

DOI:10.6004/jadpro.2022.13.3.32
PMID:35663170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9126330/
Abstract

Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder characterized by the destruction of platelets and megakaryocytes. Its management has changed significantly in recent years, and at JADPRO Live Virtual 2021, David Hughes, PharmD, BCOP, reviewed the background and pathophysiology of ITP and clinical practice guidelines with an emphasis on patient preference when selecting first and subsequent lines of therapies in the chronic ITP setting.

摘要

免疫性血小板减少症(ITP)是一种获得性自身免疫性出血性疾病,其特征为血小板和巨核细胞的破坏。近年来,其治疗方法发生了显著变化。在2021年JADPRO现场虚拟会议上,药学博士、肿瘤药学委员会认证专家大卫·休斯回顾了ITP的背景和病理生理学以及临床实践指南,重点讨论了在慢性ITP情况下选择一线及后续治疗方案时患者的偏好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f71/9126330/d37673956ece/jadpro-13-337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f71/9126330/d37673956ece/jadpro-13-337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f71/9126330/d37673956ece/jadpro-13-337-g001.jpg

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The 4 T's of ITP: Tailoring Therapies to Treat Thrombocytopenia.免疫性血小板减少症的4T原则:量身定制治疗血小板减少症的疗法
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本文引用的文献

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Mycophenolate Mofetil for First-Line Treatment of Immune Thrombocytopenia.霉酚酸酯用于一线治疗免疫性血小板减少症。
N Engl J Med. 2021 Sep 2;385(10):885-895. doi: 10.1056/NEJMoa2100596.
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Fostamatinib is an effective second-line therapy in patients with immune thrombocytopenia.福他替尼是免疫性血小板减少症患者有效的二线治疗药物。
Br J Haematol. 2020 Sep;190(6):933-938. doi: 10.1111/bjh.16959. Epub 2020 Jul 23.
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American Society of Hematology 2019 guidelines for immune thrombocytopenia.美国血液学会 2019 年免疫性血小板减少症治疗指南。
Blood Adv. 2019 Dec 10;3(23):3829-3866. doi: 10.1182/bloodadvances.2019000966.
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Updated international consensus report on the investigation and management of primary immune thrombocytopenia.更新的原发性免疫性血小板减少症的调查和管理国际共识报告。
Blood Adv. 2019 Nov 26;3(22):3780-3817. doi: 10.1182/bloodadvances.2019000812.
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Immune Thrombocytopenia.免疫性血小板减少症
N Engl J Med. 2019 Sep 5;381(10):945-955. doi: 10.1056/NEJMcp1810479.
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Rituximab in the treatment of immune thrombocytopenia: what is the role of this agent in 2019?利妥昔单抗治疗免疫性血小板减少症:2019 年该药的作用是什么?
Haematologica. 2019 Jun;104(6):1124-1135. doi: 10.3324/haematol.2019.218883. Epub 2019 May 24.
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Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia.三期随机研究avatrombopag,一种新型的促血小板生成素受体激动剂,用于治疗慢性免疫性血小板减少症。
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Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials.福他替尼治疗成人持续性和慢性免疫性血小板减少症:两项 3 期、随机、安慰剂对照试验的结果。
Am J Hematol. 2018 Jul;93(7):921-930. doi: 10.1002/ajh.25125. Epub 2018 May 15.
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Initial romiplostim dosing and time to platelet response in patients with treatment refractory immune thrombocytopenia.难治性免疫性血小板减少症患者的初始罗米司亭剂量及血小板反应时间。
J Oncol Pharm Pract. 2019 Apr;25(3):567-576. doi: 10.1177/1078155217748470. Epub 2018 Jan 3.
10
High-dose dexamethasone vs prednisone for treatment of adult immune thrombocytopenia: a prospective multicenter randomized trial.大剂量地塞米松与泼尼松治疗成人免疫性血小板减少症:一项前瞻性多中心随机试验。
Blood. 2016 Jan 21;127(3):296-302; quiz 370. doi: 10.1182/blood-2015-07-659656. Epub 2015 Oct 19.