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抑郁症的生物学机制及可能的一级预防

Biological mechanisms and possible primary prevention of depression.

作者信息

Kuo Chih-Yun, Stachiv Ivo

机构信息

Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University, Prague 12108, Czech Republic.

Department of Functional Materials, Institute of Physics, Czech Academy of Sciences, Praha 18021, Czech Republic.

出版信息

World J Psychiatry. 2022 May 19;12(5):770-772. doi: 10.5498/wjp.v12.i5.770.

DOI:10.5498/wjp.v12.i5.770
PMID:35663300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9150037/
Abstract

Individuals with unipolar depressive disorder (UDD) are having an increased risk of death and development of dementia in later life. It is widely expected that in a near future UDD would be the leading cause of death; therefore, a primary inexpensive prevention of UDD will be of a great importance to the society. Several studies provide evidences supporting the positive effect of Mediterranean diet on a reduced risk for development of depression.

摘要

单相抑郁症（UDD）患者在晚年有更高的死亡风险和患痴呆症的风险。人们普遍预计，在不久的将来，UDD将成为主要死因；因此，对UDD进行初步的低成本预防对社会至关重要。多项研究提供了证据，支持地中海饮食对降低患抑郁症风险具有积极作用。

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本文引用的文献

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World J Psychiatry. 2021 Nov 19;11(11):997-1016. doi: 10.5498/wjp.v11.i11.997.
2
Diet and depression: exploring the biological mechanisms of action.饮食与抑郁：探索作用的生物学机制。
Mol Psychiatry. 2021 Jan;26(1):134-150. doi: 10.1038/s41380-020-00925-x. Epub 2020 Nov 3.
3
Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer's Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia.老年期抑郁症、（不可）改变的风险和保护因素与痴呆和阿尔茨海默病的关联：当前证据、预防干预措施以及痴呆症预防和治疗的可能未来趋势的文献综述。
Int J Environ Res Public Health. 2020 Oct 14;17(20):7475. doi: 10.3390/ijerph17207475.
4
Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies.健康饮食指数与抑郁结局风险：观察性研究的系统评价和荟萃分析。
Mol Psychiatry. 2019 Jul;24(7):965-986. doi: 10.1038/s41380-018-0237-8. Epub 2018 Sep 26.
5
Diet quality and depression risk: A systematic review and dose-response meta-analysis of prospective studies.饮食质量与抑郁风险：前瞻性研究的系统评价和剂量反应荟萃分析。
J Affect Disord. 2018 Jan 15;226:346-354. doi: 10.1016/j.jad.2017.09.022. Epub 2017 Sep 23.