Fimiani M, Alessandrini C, Castelli A, Mancianti M L, Andreassi L
Arch Dermatol Res. 1986;279(2):77-82. doi: 10.1007/BF00417526.
Lichen nitidus (LN) and lichen planus (LP) are considered by some investigators to be two variants of the same disease, and by others to be two distinct dermatoses. In order to obtain further information about the relationship between LN and LP we examined the ultrastructure of lesions from two LN patients. In the central part of the lesion, the basement membrane was absent, or was interrupted by migrating phagocytes or lymphocytes. The basal cells and the lower cells of the stratum spinosum exhibited karyolysis and appeared to be compressed and often necrotic. In the upper dermis irregular cell debris full of clumps of tonofilaments and colloid-body-like structures was observed. A dense dermal infiltrate of macrophages, lymphocytes, fibrocytes, and Sezary-like cells was present. Signs of cooperation between lymphocytes and macrophages were also evident. The periphery of the lesion showed no pathological features except for enlargement of the intercellular spaces and the presence of mononuclear cells scattered through the epidermis. Several normal Langerhans cells were noticed. These ultrastructural findings were quite similar to those reported for LP.
光泽苔藓（LN）和扁平苔藓（LP）被一些研究者认为是同一种疾病的两种变体，而被另一些研究者认为是两种不同的皮肤病。为了获取关于LN和LP之间关系的更多信息，我们检查了两名LN患者皮损的超微结构。在皮损中央部分，基底膜缺失，或被游走的吞噬细胞或淋巴细胞中断。基底细胞和棘层下部细胞出现核溶解，似乎受到挤压且常发生坏死。在上层真皮中，观察到不规则的细胞碎片，充满了角蛋白丝束和类胶样小体结构。存在巨噬细胞、淋巴细胞、纤维细胞和Sezary样细胞的密集真皮浸润。淋巴细胞和巨噬细胞之间的协同迹象也很明显。皮损周边除细胞间隙增宽和表皮散在单核细胞外，无病理特征。还注意到几个正常的朗格汉斯细胞。这些超微结构发现与报道的LP的超微结构发现非常相似。
