Johnston Charlotte H, Whittaker Alexandra L, Franklin Samantha H, Hutchinson Mark R
Faculty of Health Sciences, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, SA, Australia.
Front Neurosci. 2022 May 19;16:887042. doi: 10.3389/fnins.2022.887042. eCollection 2022.
Communication between the central nervous system (CNS) and the immune system has gained much attention for its fundamental role in the development of chronic and pathological pain in humans and rodent models. Following peripheral nerve injury, neuroimmune signaling within the CNS plays an important role in the pathophysiological changes in pain sensitivity that lead to chronic pain. In production animals, routine husbandry procedures such as tail docking and castration, often involve some degree of inflammation and peripheral nerve injury and consequently may lead to chronic pain. Our understanding of chronic pain in animals is limited by the difficulty in measuring this pathological pain state. In light of this, we have reviewed the current understanding of chronic pain in production animals. We discuss our ability to measure pain and the implications this has on animal welfare and production outcomes. Further research into the neuroimmune interface in production animals will improve our fundamental understanding of chronic pain and better inform human clinical pain management and animal husbandry practices and interventions.
中枢神经系统（CNS）与免疫系统之间的通讯因其在人类和啮齿动物模型慢性和病理性疼痛发展中的重要作用而备受关注。外周神经损伤后，中枢神经系统内的神经免疫信号在导致慢性疼痛的疼痛敏感性病理生理变化中起重要作用。在生产动物中，诸如断尾和阉割等常规饲养程序通常会涉及一定程度的炎症和外周神经损伤，因此可能导致慢性疼痛。我们对动物慢性疼痛的理解受到测量这种病理疼痛状态难度的限制。有鉴于此，我们回顾了目前对生产动物慢性疼痛的认识。我们讨论了测量疼痛的能力及其对动物福利和生产结果的影响。对生产动物神经免疫界面的进一步研究将增进我们对慢性疼痛的基本理解，并为人类临床疼痛管理以及动物饲养实践和干预提供更好的信息。
