Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, Adelaide, South Australia, 5005, Australia.
Adelaide Medical School, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Animal. 2019 Dec;13(12):3000-3008. doi: 10.1017/S1751731119001885. Epub 2019 Aug 13.
It has taken more than 40 years for the fields of immunology and neuroscience to capture the potential impact of the mechanistic understanding of how an active immune signalling brain might function. These developments have grown an appreciation for the immunocompetent cells of the central nervous system and their key role in the health and disease of the brain and spinal cord. Moreover, the understanding of the bidirectional communication between the brain and the peripheral immune system has evolved to capture an understanding of how mood can alter immune function and vice versa. These concepts are rapidly evolving the field of psychiatry and medicine as a whole. However, the advances in human medicine have not been capitalised upon yet in animal husbandry practice. Of specific attention are the implications that these biological systems have for creating and maintaining heightened pain states. This review will outline the key concepts of brain-immune communication and the immediate opportunities targeting this biology can have for husbandry practices, with a specific focus on pain.
免疫学和神经科学领域花了 40 多年的时间才认识到，深入了解活跃的免疫信号大脑如何发挥作用，具有潜在的影响。这些发展使人们更加关注中枢神经系统的免疫活性细胞及其在大脑和脊髓的健康和疾病中的关键作用。此外，人们对大脑与外周免疫系统之间双向通讯的理解也在不断发展，以了解情绪如何改变免疫功能，反之亦然。这些概念正在迅速改变整个精神病学和医学领域。然而，这些在人类医学上的进展尚未在畜牧业实践中得到充分利用。特别值得关注的是，这些生物系统对产生和维持高度疼痛状态的影响。本文将概述大脑-免疫通讯的关键概念，以及针对这种生物学的即时机会对畜牧业实践的影响，重点关注疼痛。
