用于分析高电荷硫酸化碳水化合物的质谱法
Mass Spectrometry for the Analysis of Highly Charged Sulfated Carbohydrates.
作者信息
Chi Lianli, Amster Jonathan, Linhardt Robert J
机构信息
Department of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Deparment of Chemistry, University of Georgia, Athens, GA 30602, USA.
出版信息
Curr Anal Chem. 2005;1(3):223-240. doi: 10.2174/157341105774573929.
Abstract
Sulfated polysaccharides and their oligosaccharide components play an important biological role in physiological and pathophysiological processes. Glycosaminoglycans, such as heparin, are currently used as pharmaceutical agents to control coagulation. Moreover, there arc intensive efforts in developing rapid approaches for the analysis of such bioactive carbohydrates to assess their pharmacological activity and in glycomic applications. Soft ionization methods of mass spectrometry have been applied with recent success in the analysis of sulfated carbohydrates. This review will examine the application of mass spectrometry in the compositional analysis and structural characterization of these important highly charged molecules.
摘要
硫酸化多糖及其寡糖成分在生理和病理生理过程中发挥着重要的生物学作用。糖胺聚糖，如肝素，目前被用作控制凝血的药物。此外，人们正在大力开发快速分析此类生物活性碳水化合物的方法，以评估其药理活性并用于糖组学应用。质谱软电离方法最近已成功应用于硫酸化碳水化合物的分析。本综述将探讨质谱在这些重要的高电荷分子的组成分析和结构表征中的应用。
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