Theunissen Eef Lien, Kuypers Kim Paula Colette, Mason Natasha Leigh, Ramaekers Johannes Gerardus
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.
Front Psychiatry. 2022 May 19;13:891811. doi: 10.3389/fpsyt.2022.891811. eCollection 2022.
Due to differences in potency, efficacy, and affinity for CB1 receptors, similarities and differences in psychoactive effect profiles of natural cannabis and synthetic cannabinoids (SCs) cannot reliably be derived from equipotent dose comparisons. Instead, the current study proposes to compare the intrinsic psychoactive effects of natural cannabis (THC) and an SC, JWH-018, at psychotropic dose equivalence. Participants from two placebo-controlled studies were matched for their levels of subjective high to compare neurocognitive and psychotomimetic effects of THC and JWH-018. At equal subjective intoxication levels, both drugs impaired psychomotor, divided attention, and impulse control, with no significant difference between the two drugs. Both drugs also caused significant psychotomimetic effects, but dissociative effects were considerably more pronounced for JWH-018 than THC. We conclude that psychotropic dose equivalence provides a uniform approach for comparing the neurocognitive and psychotomimetic profiles of CB1 agonists, which can also be applied to other drug classes.
由于天然大麻和合成大麻素（SCs）对CB1受体的效力、功效和亲和力存在差异，因此无法通过等效剂量比较可靠地得出它们精神活性效应概况的异同。相反，当前研究建议在精神活性剂量等效的情况下比较天然大麻（THC）和一种合成大麻素JWH-018的内在精神活性效应。来自两项安慰剂对照研究的参与者根据主观兴奋程度进行匹配，以比较THC和JWH-018的神经认知和拟精神病效应。在同等主观中毒水平下，两种药物均损害精神运动、分散注意力和冲动控制能力，两者之间无显著差异。两种药物还均引起显著的拟精神病效应，但JWH-018的分离效应比THC更为明显。我们得出结论，精神活性剂量等效为比较CB1激动剂的神经认知和拟精神病概况提供了一种统一的方法，该方法也可应用于其他药物类别。
