带有可电化学裂解的1-(6-甲基吡啶-2-甲基)保护基的四唑的官能化
Functionalization of Tetrazoles Bearing the Electrochemically Cleavable 1-(6-Methylpyridyl-2-methyl) Protecting Group.
作者信息
Grammatoglou Konstantinos, Da Rziņa Madara, Jirgensons Aigars
机构信息
Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006 Riga, Latvia.
出版信息
ACS Omega. 2022 May 16;7(21):18103-18109. doi: 10.1021/acsomega.2c01633. eCollection 2022 May 31.
Abstract
6-Methylpyridyl-2-methyl protected tetrazoles can be C-H deprotonated using the turbo-Grignard reagent and involved in the reactions with aldehydes and ketones. The protecting group can be cleaved under reductive electrochemical conditions using Pb bronze as a cathode and Zn as a sacrificial anode.
摘要
6-甲基吡啶-2-甲基保护的四氮唑可以使用Turbo-格氏试剂进行C-H去质子化，并参与与醛和酮的反应。使用铅青铜作为阴极、锌作为牺牲阳极，在还原电化学条件下可以裂解保护基。
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