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官能团保护与脱保护的可持续方法。

Sustainable Approaches for the Protection and Deprotection of Functional Groups.

作者信息

Jin Ju Ha, An Mina, Jeon Minki, Kim Jaejeong, Kang Sung Min, Choi Isaac

机构信息

Department of Chemistry, Chungbuk National University, Chungcheongbuk-do, 28644, Republic of Korea.

Daeso Plant, High Tech Pharm, Chungcheongbuk-do, 27663, Republic of Korea.

出版信息

Chemistry. 2025 Jul 17;31(40):e202501387. doi: 10.1002/chem.202501387. Epub 2025 Jun 27.

DOI:10.1002/chem.202501387
PMID:40530929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12272020/
Abstract

While functional group tolerance is a critical consideration in synthetic method development, many functional groups often fail to remain intact under diverse reaction conditions. Therefore, the protection of specific functional groups and subsequent deprotection are convenient choices for the efficient and selective synthesis of target compounds, for which the strategies have been securely established. Meanwhile, the development of sustainable synthetic methods, particularly electrochemistry and photochemistry, has recently played a significant role in the field of organic synthesis, and these approaches have proven useful in the methods of functional group protection and deprotection. This review explores electrochemical and photochemical strategies for the protection and deprotection of functional groups, with a focus on their mechanistic diversity, sustainability, and synthetic utility across various functional group classes.

摘要

虽然官能团耐受性是合成方法开发中的关键考虑因素，但许多官能团在不同的反应条件下往往无法保持完整。因此，特定官能团的保护及其后的脱保护是高效、选择性合成目标化合物的便捷选择，其策略已得到可靠确立。同时，可持续合成方法的发展，特别是电化学和光化学，最近在有机合成领域发挥了重要作用，并且这些方法已被证明在官能团保护和脱保护方法中很有用。本综述探讨了官能团保护和脱保护的电化学和光化学策略，重点关注其机理多样性、可持续性以及在各种官能团类别中的合成效用。

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2
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3
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