Tormo B, Rodríguez T, Rengifo E, Mandado S, González N, Gra B
Arch Geschwulstforsch. 1987;57(1):39-46.
A previous report of members of our group demonstrated, in most adenocarcinomas and some adenomatous polyps with areas of malignant transformation, the presence of glycogen in cells that failed to show the synthesis of ordinary mucosubstances. The presence of glycogen in non-differentiated epithelium of the digestive tract of embryos, where it precedes ordinary mucus secretion, has lead some authors to suggest that the changes to glycogen secretion that occurs in malignant colonic cells, reflects the general regression to a less differentiated level of structure and function. It is well established that patients with carcinomas of the colon classified as less differentiated or higher grade tumors have significantly less chance of cure and consequently a worse prognosis than patients with lower grade tumors. The present ultrastructural study of the morphological differentiation characteristics of the glycogen containing cells previously encountered, revealed a strong association of glycogen to undifferentiated cells of the colonic adenocarcinomas and precancerous polypoid lesions studied. This undoubtedly seems to encourage the testing for the presence of glycogen in routine procedures as a possible marker of diagnostic and prognostic significance.
我们团队之前的一份报告显示，在大多数腺癌以及一些发生恶性转化区域的腺瘤性息肉中，未能显示出普通粘膜物质合成的细胞中存在糖原。在胚胎消化道的未分化上皮中存在糖原，且其先于普通粘液分泌，这使得一些作者认为，恶性结肠细胞中发生的糖原分泌变化反映了结构和功能向分化程度较低水平的总体退化。众所周知，被归类为低分化或高级别肿瘤的结肠癌患者治愈的机会明显较少，因此与低级别肿瘤患者相比预后更差。目前对先前发现的含糖原细胞的形态分化特征进行的超微结构研究表明，在所研究的结肠腺癌和癌前息肉样病变的未分化细胞中，糖原与它们有很强的关联。这无疑似乎鼓励在常规程序中检测糖原的存在，作为一种可能具有诊断和预后意义的标志物。
