Involvement of the Gene in Confrontation of Environmental Pressure.

Actinobacillus pleuropneumoniae causes porcine pleuropneumonia. The function of the outer membrane protein W gene () of has not been evaluated. Thus a deletion mutant of , Δ, was constructed to explore the effect of gene deletion on bacterial growth, biofilm formation, bacterial morphology, oxidative tolerance, susceptibility to antibiotics, and the expression of ribosome synthesis and ABC transporter related genes. Results showed that the gene deletion did not affect biofilm formation and the growth of but did affect bacterial morphology during steady growth, oxidative tolerance, and bacterial susceptibility to polymyxin B, kanamycin, and penicillin. The gene deletion also affected the expression of ribosome synthesis and ABC transporter related genes. These results suggested that may regulate the biological phenotype of .