Liu Meng, Zhang Zheng, Qin Chunli, Lv Bingqiang, Mo Shiwei, Lan Tao, Gao Binghong
College of Physical Education and Training, Shanghai University of Sport, Shanghai, China.
Chongqing Institute of Sport Science, Chongqing, China.
Front Physiol. 2022 May 19;13:886254. doi: 10.3389/fphys.2022.886254. eCollection 2022.
This study aimed to investigate the effects of 4-week tangeretin supplementation on the cortisol stress response induced by high-intensity resistance exercise. A randomized controlled trial of twenty-four soccer players was conducted during the winter training season. The experimental group (EG) took the oral supplement with tangeretin (200 mg/day) and the control group (CG) took placebo for 4 weeks. Before and after the 4-week intervention, all players performed a high intensity bout of resistance exercise to stimulate their cortisol stress responses. Serum cortisol, adreno-corticotropic hormone (ACTH) and superoxide dismutase (SOD) were obtained by collecting blood samples before (PRE), immediately after (P0), and 10 (P10), 20 (P20) and 30 minutes (P30) after the exercise. The serum cortisol level (PRE, = 0.017; P10, = 0.010; P20, = 0.014; P30, = 0.007) and ACTH (P10, = 0.037; P30, = 0.049) of experimental group significantly decreased after the 4-week intervention. Compared with control group, EG displayed a significantly lower level of the serum cortisol (PRE, = 0.036; P10, = 0.031) and ACTH (P30, = 0.044). Additionally, EG presented significantly higher superoxide dismutase activity level compared with CG at P30 ( = 0.044). The white blood cell of EG decreased significantly (PRE, = 0.037; P30, = 0.046) and was significantly lower than CG at P20 ( = 0.01) and P30 ( = 0.003). Four-week tangeretin supplementation can reduce serum cortisol and ACTH, which may ameliorate the cortisol stress response in soccer players during high-intensity resistance exercise training. It can also enhance antioxidant capacity, accelerate the elimination of inflammation throughout the body, and shorten recovery time after high-intensity exercise.
本研究旨在探讨连续4周补充陈皮素对高强度抗阻运动诱导的皮质醇应激反应的影响。在冬季训练期间，对24名足球运动员进行了一项随机对照试验。实验组（EG）口服补充陈皮素（200毫克/天），对照组（CG）服用安慰剂，为期4周。在为期4周的干预前后，所有运动员都进行了一次高强度抗阻运动，以刺激他们的皮质醇应激反应。通过在运动前（PRE）、运动后即刻（P0）以及运动后10分钟（P10）、20分钟（P20）和30分钟（P30）采集血样，获取血清皮质醇、促肾上腺皮质激素（ACTH）和超氧化物歧化酶（SOD）。4周干预后，实验组的血清皮质醇水平（PRE，P = 0.017；P10，P = 0.010；P20，P = 0.014；P30，P = 0.007）和ACTH（P10，P = 0.037；P30，P = 0.049）显著降低。与对照组相比，实验组的血清皮质醇（PRE，P = 0.036；P10，P = 0.031）和ACTH（P30，P = 0.044）水平显著更低。此外，在P30时，实验组的超氧化物歧化酶活性水平显著高于对照组（P = 0.044）。实验组的白细胞显著减少（PRE，P = 0.037；P30，P = 0.046），且在P20（P = 0.01）和P30（P = 0.003）时显著低于对照组。连续4周补充陈皮素可降低血清皮质醇和ACTH，这可能改善足球运动员在高强度抗阻运动训练期间的皮质醇应激反应。它还可以增强抗氧化能力，加速全身炎症的消除，并缩短高强度运动后的恢复时间。
