Sheibani Mehdi, Zamani Nasim, Gerami Amir Hushang, Akhondi Hossein, Hassanian-Moghaddam Hossein
Cardiovascular Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.
Department of Clinical Toxicology, Loghman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Med (Lausanne). 2022 May 19;9:872528. doi: 10.3389/fmed.2022.872528. eCollection 2022.
We aimed to investigate the clinical, laboratory, and electrocardiographic (ECG) findings of colchicine poisoning and to evaluate if there is a correlation between them and the two major outcomes of this toxicity which are respiratory/cardiovascular failure and death.
Medical records of 34 colchicine-intoxicated patients that were treated in our center during the past 10 years were retrospectively evaluated. The patient's clinical presentation, vital signs, laboratory tests, ECGs, and outcomes were reviewed.
Abdominal pain, and hypotension at presentation had significant correlation with mortality ( = 0.003, OR: 2.2 [4.1, 7.9], = 0.029, OR: 13.0 [1.5, 111.8]). Mortality significantly occurred in those with sinus tachycardia, hypokalemia, metabolic acidosis, and impaired liver and kidney function tests (-values = 0.025, 0.007, 0.04, and 0.008, respectively). All the patients had some ECG abnormalities. Most frequent ECG abnormalities were pathologic ST segment elevation and depression (70%), left atrial enlargement (48%), and sinus tachycardia (37%), PR elevation in aVR lead (37%), and T wave inversion (37%).
Colchicine toxicity is a dangerous entity regarding the cardiovascular events and requires close general and cardiac monitoring.
我们旨在研究秋水仙碱中毒的临床、实验室及心电图（ECG）表现，并评估这些表现与该毒性的两个主要结局（呼吸/心血管衰竭和死亡）之间是否存在相关性。
回顾性评估过去10年在我们中心接受治疗的34例秋水仙碱中毒患者的病历。对患者的临床表现、生命体征、实验室检查、心电图及结局进行了回顾。
就诊时腹痛和低血压与死亡率显著相关（P = 0.003，OR：2.2 [4.1, 7.9]；P = 0.029，OR：13.0 [1.5, 111.8]）。窦性心动过速、低钾血症、代谢性酸中毒以及肝肾功能检查异常的患者死亡率显著升高（P值分别为0.025、0.007、0.04和0.008）。所有患者均有一些心电图异常。最常见的心电图异常为病理性ST段抬高和压低（70%）、左心房增大（48%）、窦性心动过速（37%）、aVR导联PR段抬高（37%）以及T波倒置（37%）。
秋水仙碱毒性在心血管事件方面是一个危险情况，需要密切的综合及心脏监测。
