Al Megalli Moussa, Bashir Shahid, Qadah Hanaa, Ameen Omar, Al-Harbi Talal M
Neurology, Heraa General Hospital, Makkah, SAU.
Neuroscience Center, King Fahad Specialist Hospital, Dammam, SAU.
Cureus. 2021 Dec 9;13(12):e20290. doi: 10.7759/cureus.20290. eCollection 2021 Dec.
Colchicine-induced myopathy has been described in patients with chronic renal failure and patients who are using a concomitant drug like a statin. However, pure myopathy caused by colchicine has never been reported in Saudi Arabia. A 64-year-old patient received colchicine for his gout arthritis disease and developed upper and lower limb weakness. He had a proximal weakness, and his muscle enzymes were very high. Furthermore, the needle electromyography (EMG) examination showed abundant fibrillations, myotonic discharges, and myopathic motor units. Two weeks after colchicine cessation, his weakness improved dramatically with normalization of creatine kinase (CK) and disappearance of myotonic discharges in the repeated EMG. This is the first case in Saudi Arabia that showed colchicine-induced myositis. The local clinicians' community needs to be aware of this rare side effect, as clinical suspicion is the most important diagnostic clue and the only effective treatment is the termination of colchicine.
秋水仙碱诱发的肌病已在慢性肾衰竭患者以及正在使用他汀类药物等伴随药物的患者中有所描述。然而，沙特阿拉伯从未报道过由秋水仙碱引起的单纯性肌病。一名64岁的患者因痛风性关节炎接受秋水仙碱治疗后出现上下肢无力。他有近端肌无力，肌肉酶水平非常高。此外，针极肌电图（EMG）检查显示有大量纤颤电位、肌强直放电和肌病性运动单位。停用秋水仙碱两周后，他的肌无力显著改善，肌酸激酶（CK）恢复正常，重复肌电图检查中肌强直放电消失。这是沙特阿拉伯首例显示秋水仙碱诱发肌炎的病例。当地临床医生群体需要意识到这种罕见的副作用，因为临床怀疑是最重要的诊断线索，而唯一有效的治疗方法是停用秋水仙碱。
