一种脂质 ALC-0315 的合成路线：一种 COVID-19 mRNA 疫苗的关键组成部分。
A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine.
机构信息
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
出版信息
Chemistry. 2022 Aug 26;28(48):e202200906. doi: 10.1002/chem.202200906. Epub 2022 Jul 4.
Abstract
This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.
摘要
本文描述了通过一种序列合成 ALC-0315，该序列使总收率相对于已发表的方法提高了一倍以上，并且采用了更为清洁的反应，从而在很大程度上促进了纯化。
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