急性剂量乙醇对大鼠肝脏微粒体混合功能氧化酶成分及膜脂质组成的影响。
Effect of an acute dose of ethanol on rat liver microsomal mixed function oxygenase components and membrane lipid composition.
作者信息
Pennington S N, Smith C P, Tapscott E B
出版信息
Alcohol Clin Exp Res. 1978 Jul;2(3):311-6. doi: 10.1111/j.1530-0277.1978.tb05819.x.
Abstract
The lipid composition of rat liver microsomes was not altered in response to a single acute dose of ethanol relative to isocaloric glycerol-treated controls. Microsomal cytochrome P-450 was transiently elevated, the elevation paralleling blood ethanol levels. Microsomal NADPH oxidase was transiently elevated relative to the activity in isocaloric glycerol-treated controls.
摘要
与等热量甘油处理的对照组相比，单次急性给予乙醇后，大鼠肝脏微粒体的脂质组成未发生改变。微粒体细胞色素P-450短暂升高，升高情况与血液乙醇水平平行。相对于等热量甘油处理的对照组的活性，微粒体NADPH氧化酶短暂升高。
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