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胶固素的碳水化合物特异性及其与肝脏凝集素家族中蛋白质的同源性。

The carbohydrate specificity of conglutinin and its homology to proteins in the hepatic lectin family.

作者信息

Young N M, Leon M A

出版信息

Biochem Biophys Res Commun. 1987 Mar 13;143(2):645-51. doi: 10.1016/0006-291x(87)91402-1.

DOI:10.1016/0006-291x(87)91402-1
PMID:3566740
Abstract

Inhibition experiments with D-mannose oligosaccharides establish that conglutinin recognises terminal alpha 1----2 mannobiosyl units present in the glycopeptide of the alpha-chain of the complement component C3b. On the basis of its three domain structure and the homology of its N-terminal amino-acid sequence to that of the dog pulmonary surfactant protein, it is proposed that conglutinin is a member of the hepatic lectin family.

摘要

用D-甘露糖寡糖进行的抑制实验表明，凝聚素可识别补体成分C3bα链糖肽中存在的末端α1----2甘露二糖基单元。基于其三个结构域的结构以及其N端氨基酸序列与犬肺表面活性蛋白的同源性，有人提出凝聚素是肝凝集素家族的一员。

相似文献

1
The carbohydrate specificity of conglutinin and its homology to proteins in the hepatic lectin family.胶固素的碳水化合物特异性及其与肝脏凝集素家族中蛋白质的同源性。
Biochem Biophys Res Commun. 1987 Mar 13;143(2):645-51. doi: 10.1016/0006-291x(87)91402-1.
2
Expression of the carbohydrate recognition domain of bovine conglutinin and demonstration of its binding to iC3b and yeast mannan.牛凝集素碳水化合物识别结构域的表达及其与iC3b和酵母甘露聚糖结合的证明。
Biochem Biophys Res Commun. 1996 Jan 5;218(1):260-6. doi: 10.1006/bbrc.1996.0046.
3
Bovine serum conglutinin is a lectin which binds non-reducing terminal N-acetylglucosamine, mannose and fucose residues.牛血清胶固素是一种凝集素，它能结合非还原性末端的N-乙酰葡糖胺、甘露糖和岩藻糖残基。
Biochem J. 1989 Feb 15;258(1):109-13. doi: 10.1042/bj2580109.
4
Comparative study of the structural and functional properties of a bovine plasma C-type lectin, collectin-43, with other collectins.牛血浆C型凝集素collectin-43与其他凝集素的结构和功能特性的比较研究。
Biochem J. 1995 Feb 1;305 ( Pt 3)(Pt 3):889-96. doi: 10.1042/bj3050889.
5
Studies on the carbohydrate-binding characteristics of human pulmonary surfactant-associated protein A and comparison with two other collectins: mannan-binding protein and conglutinin.人肺表面活性物质相关蛋白A的碳水化合物结合特性研究及其与另外两种凝集素：甘露聚糖结合蛋白和胶固素的比较。
Biochem J. 1993 Aug 1;293 ( Pt 3)(Pt 3):873-8. doi: 10.1042/bj2930873.
6
Differentiation of conglutination activity and sugar-binding activity of conglutinin after removal of NH2-terminal 54 amino acid residues by endogenous serine protease(s).通过内源性丝氨酸蛋白酶去除氨基末端54个氨基酸残基后，凝集素的凝集活性和糖结合活性的分化。
Arch Biochem Biophys. 1993 Sep;305(2):533-40. doi: 10.1006/abbi.1993.1457.
7
Purification and characterization of a bovine serum lectin (CL-43) with structural homology to conglutinin and SP-D and carbohydrate specificity similar to mannan-binding protein.一种与胶固素和表面活性蛋白D结构同源且碳水化合物特异性与人甘露糖结合蛋白相似的牛血清凝集素（CL-43）的纯化与特性分析
J Biol Chem. 1993 May 15;268(14):10120-5.
8
Bovine conglutinin binds to an oligosaccharide determinant presented by iC3b, but not by C3, C3b or C3c.牛胶固素与iC3b呈现的一种寡糖决定簇结合，但不与C3、C3b或C3c结合。
Immunology. 1994 Apr;81(4):648-54.
9
Collectin-43 is a serum lectin with a distinct pattern of carbohydrate recognition.Collectin-43是一种具有独特碳水化合物识别模式的血清凝集素。
Immunology. 1995 Aug;85(4):651-9.
10
Purification, subunit characterization and ultrastructure of three soluble bovine lectins: conglutinin, mannose-binding protein and the pentraxin serum amyloid P-component.三种可溶性牛凝集素的纯化、亚基特性及超微结构：胶固素、甘露糖结合蛋白和五聚体血清淀粉样蛋白P成分
Scand J Immunol. 1992 Jul;36(1):131-41. doi: 10.1111/j.1365-3083.1992.tb02949.x.

引用本文的文献

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Nat Commun. 2022 Apr 12;13(1):1955. doi: 10.1038/s41467-022-29580-2.
2
Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with -acetylglucosamine.牛免疫蛋白血纤维蛋白原的原子分辨率晶体结构揭示了其结合位点与 N-乙酰葡萄糖胺的特定相互作用。
J Biol Chem. 2019 Nov 8;294(45):17155-17165. doi: 10.1074/jbc.RA119.010271. Epub 2019 Sep 27.
3
Mammalian lectins in activation and clearance mechanisms involving the complement system.
参与补体系统的激活和清除机制的哺乳动物凝集素。
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4
Bovine conglutinin binds to an oligosaccharide determinant presented by iC3b, but not by C3, C3b or C3c.牛胶固素与iC3b呈现的一种寡糖决定簇结合，但不与C3、C3b或C3c结合。
Immunology. 1994 Apr;81(4):648-54.
5
Bovine serum conglutinin is a lectin which binds non-reducing terminal N-acetylglucosamine, mannose and fucose residues.牛血清胶固素是一种凝集素，它能结合非还原性末端的N-乙酰葡糖胺、甘露糖和岩藻糖残基。
Biochem J. 1989 Feb 15;258(1):109-13. doi: 10.1042/bj2580109.
6
Inhibition of human immunodeficiency virus-1 infection by human conglutinin-like protein: in vitro studies.人凝集素样蛋白对人免疫缺陷病毒-1感染的抑制作用：体外研究
Jpn J Cancer Res. 1992 May;83(5):458-64. doi: 10.1111/j.1349-7006.1992.tb01950.x.
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Purification, characterization and cDNA cloning of human lung surfactant protein D.人肺表面活性物质蛋白D的纯化、特性鉴定及cDNA克隆
Biochem J. 1992 Jun 15;284 ( Pt 3)(Pt 3):795-802. doi: 10.1042/bj2840795.