Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No. 81 Meishan Road, Hefei 230032, Anhui, China; Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei 230022, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No. 81 Meishan Road, Hefei 230032, Anhui, China.
Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No. 81 Meishan Road, Hefei 230032, Anhui, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China.
Ecotoxicol Environ Saf. 2022 Aug;241:113837. doi: 10.1016/j.ecoenv.2022.113837. Epub 2022 Jul 4.
Evidence of the influence of prenatal phthalate exposure on childhood longitudinal obesity markers is limited. Nested on the Ma'anshan birth cohort study, 990 mother-daughter pairs were included. Seven phthalate metabolites were determined in urine collected in each trimester. Each child underwent a physical examination from birth to 6 years of age twelve times. Latent class growth models were used to identify three trajectories of girls' body mass index (BMI). Logistic regression, quantile g-computation and Bayesian kernel machine regression models analyzed the relationships of prenatal exposure to individual and mixed phthalates with girls' body mass index (BMI) trajectory. Compared to the "lowest trajectory" class, prenatal average concentrations of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP, OR = 2.095, 95 % CI = 1.014-4.328) and di(2-ethylhexyl) phthalate (DEHP, OR = 2.336, 95 % CI = 1.022-5.338) during pregnancy were associated with an increased probability of being in the "highest trajectory" class. The average concentration of DEHP (OR = 1.879, 95 % CI = 1.002-3.522) was associated with an increased probability of being in the "moderate trajectory" class. Stratified analyses by trimester of pregnancy mainly showed that third-trimester exposure to monoethyl phthalate (MEP, OR = 1.584, 95 % CI = 1.094-2.292), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP, OR = 2.885, 95 % CI = 1.367-6.088), MEHHP (OR = 2.425, 95 % CI = 1.335-4.407), DEHP (OR = 2.632, 95 % CI = 1.334-5.193) and high molecular weight phthalate (OR = 2.437, 95 % CI = 1.239-4.792) was associated with an increased probability of being in the "highest trajectory" class. However, the mixture of phthalates was not significantly related to the girl's BMI trajectory. In conclusion, in utero exposure to phthalates, including MEP and DEHP metabolites (MEHHP and MEOHP), was significantly associated with early childhood high BMI trajectories in girls. The third trimester of pregnancy seemed to be the window of vulnerability to phthalate exposure for girls' high BMI trajectory at periods of prenatal development. No evidence supported a significant relationship between combined exposure to phthalate metabolites and girls' high BMI trajectory.
产前邻苯二甲酸酯暴露对儿童纵向肥胖标志物的影响的证据有限。在马鞍山市出生队列研究中，纳入了 990 对母婴对子。在每个孕期采集尿液，测定 7 种邻苯二甲酸酯代谢物。每个孩子在出生到 6 岁期间进行了 12 次体检。使用潜在类别增长模型确定女孩体重指数（BMI）的三个轨迹。逻辑回归、分位数 g 计算和贝叶斯核机器回归模型分析了产前暴露于个体和混合邻苯二甲酸酯与女孩体重指数（BMI）轨迹的关系。与“最低轨迹”类相比，妊娠期间平均浓度的单（2-乙基-5-羟基己基）邻苯二甲酸酯（MEHHP，OR = 2.095，95%CI = 1.014-4.328）和邻苯二甲酸二（2-乙基己基）酯（DEHP，OR = 2.336，95%CI = 1.022-5.338）与处于“最高轨迹”类的概率增加有关。DEHP 的平均浓度（OR = 1.879，95%CI = 1.002-3.522）与处于“中等轨迹”类的概率增加有关。按妊娠 trimester 进行的分层分析主要表明，妊娠晚期暴露于邻苯二甲酸单乙酯（MEP，OR = 1.584，95%CI = 1.094-2.292）、邻苯二甲酸单（2-乙基-5-氧己基）酯（MEOHP，OR = 2.885，95%CI = 1.367-6.088）、MEHHP（OR = 2.425，95%CI = 1.335-4.407）、DEHP（OR = 2.632，95%CI = 1.334-5.193）和高分子量邻苯二甲酸酯（OR = 2.437，95%CI = 1.239-4.792）与处于“最高轨迹”类的概率增加有关。然而，邻苯二甲酸酯混合物与女孩的 BMI 轨迹没有显著关系。总之，宫内接触邻苯二甲酸酯，包括 MEP 和 DEHP 代谢物（MEHHP 和 MEOHP），与女孩早期儿童高 BMI 轨迹显著相关。妊娠晚期似乎是女孩在产前发育阶段高 BMI 轨迹中接触邻苯二甲酸酯的脆弱窗口期。没有证据表明联合暴露于邻苯二甲酸酯代谢物与女孩高 BMI 轨迹之间存在显著关系。
