Martens G J, Weterings K A, van Zoest I D, Jenks B G
Biochem Biophys Res Commun. 1987 Mar 13;143(2):678-84. doi: 10.1016/0006-291x(87)91407-0.
In the pars intermedia of the pituitary gland of the amphibian Xenopus laevis the level of mRNA encoding proopiomelanocortin (POMC), the precursor protein for alpha-melanophore-stimulating hormone (alpha-MSH), is shown to be dependent on physiological parameters. POMC mRNA levels in the pars intermedia of black-background-adapted Xenopus are much higher than those of white-adapted animals. These physiological changes in POMC mRNA levels are tissue-specific because they were not found in the pars distalis of the pituitary gland. Background transfer experiments revealed that modulation of POMC gene activity is much slower than changes in the secretion of alpha-MSH.
在两栖动物非洲爪蟾垂体中间部，编码阿黑皮素原（POMC）——α-促黑素细胞激素（α-MSH）的前体蛋白——的mRNA水平显示取决于生理参数。适应黑色背景的非洲爪蟾垂体中间部的POMC mRNA水平远高于适应白色背景的动物。POMC mRNA水平的这些生理变化具有组织特异性，因为在垂体远侧部未发现此类变化。背景转换实验表明，POMC基因活性的调节比α-MSH分泌的变化要慢得多。
