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本文引用的文献

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Isolation and structure of another beta-melanotropin from salmon pituitary glands.从鲑鱼脑垂体中分离出另一种β-促黑素细胞激素及其结构
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Isolation of alpha-melanotropin and N, O-diacetylserine1-alpha-melanotropin from porcine pituitary extracts.从猪垂体提取物中分离α-促黑素和N,O-二乙酰丝氨酸1-α-促黑素
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Biosynthesis of two structurally different pro-opiomelanocortins in the pars intermedia of the amphibian pituitary gland.两栖动物脑垂体中间部两种结构不同的阿黑皮素原的生物合成。
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Activity of serum cytidine deaminase during pregnancy.孕期血清胞苷脱氨酶的活性
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The mouse genome contains two nonallelic pro-opiomelanocortin genes.小鼠基因组包含两个非等位的阿黑皮素原基因。
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Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene.小鼠促肾上腺皮质激素-β-促脂解素前体基因及一个相关假基因的分离与鉴定
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The human pro-opiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA.人类促阿片-黑素细胞皮质素原基因：结构、序列及与重复DNA的散布情况
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alpha-Melanocyte-stimulating hormone-like peptides in the intermediate lobe of the rat pituitary gland: characterization of content and release in vitro.大鼠垂体中间叶中α-黑素细胞刺激素样肽：体外含量与释放的特征
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非洲爪蟾垂体中两种阿片促黑激素皮质素原基因的表达：两种前激素原的完整结构

Expression of two proopiomelanocortin genes in the pituitary gland of Xenopus laevis: complete structures of the two preprohormones.

作者信息

Martens G J

出版信息

Nucleic Acids Res. 1986 May 12;14(9):3791-8. doi: 10.1093/nar/14.9.3791.

DOI:10.1093/nar/14.9.3791
PMID:3754961
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC339815/
Abstract

A number of cDNA clones corresponding to Xenopus POMC mRNA was isolated from a cDNA library constructed from Xenopus pituitary polyadenylated RNA. Characterization of the cDNA inserts revealed two groups of structurally different proopiomelanocortin mRNAs, indicating that two proopiomelanocortin genes are expressed to virtually the same level in Xenopus pituitary glands. From the mRNA structures the complete amino acid sequences of the two Xenopus preproopiomelanocortins could be deduced. Comparison with proopiomelanocortin mRNA and protein sequences from other species shows regions of high homology (including the portion of the prohormone located N-terminally of gamma-melanophore-stimulating hormone) and regions of extremely low homology (including the signal sequence).

摘要

从非洲爪蟾垂体多聚腺苷酸化RNA构建的cDNA文库中分离出了多个与非洲爪蟾阿黑皮素原mRNA对应的cDNA克隆。对cDNA插入片段的特性分析揭示了两组结构不同的阿黑皮素原mRNA，这表明在非洲爪蟾垂体中，两个阿黑皮素原基因的表达水平几乎相同。根据mRNA结构可以推断出两种非洲爪蟾前阿黑皮素原的完整氨基酸序列。与其他物种的阿黑皮素原mRNA和蛋白质序列比较显示，存在高度同源区域（包括位于γ-促黑素细胞激素N端的激素原部分）和极低同源区域（包括信号序列）。