自发性高血压大鼠红细胞内游离镁含量降低。

Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.

作者信息

Matuura T, Kohno M, Kanayama Y, Yasunari K, Murakawa K, Takeda T, Ishimori K, Morishima I, Yonezawa T

出版信息

Biochem Biophys Res Commun. 1987 Mar 30;143(3):1012-7. doi: 10.1016/0006-291x(87)90352-4.

Abstract

Using 31p-NMR (the phosphorus nuclear magnetic resonance) spectroscopy, we measured intracellular free Mg levels in the erythrocytes of untreated (n = 7) and diltiazem-treated spontaneously hypertensive rats (SHR) (n = 8), and compared them with age-matched Wistar-Kyoto rats (WKY) (n = 10). The intracellular free Mg levels were significantly (p less than 0.01) decreased in untreated SHR compared with those in control WKY. A successful antihypertensive treatment with diltiazem increased the intracellular free Mg levels compared with untreated SHR (p less than 0.05). Furthermore, an inverse correlation was observed between intracellular free Mg levels and blood pressure levels in all groups (r = -0.48, p less than 0.01, n = 25). These observations suggest that abnormalities of intracellular Mg metabolism may be, in part, related to the development or the maintenance of hypertension in SHR.

摘要

利用31P - NMR（磷核磁共振）光谱法，我们测量了未经治疗的自发性高血压大鼠（SHR）（n = 7）和地尔硫䓬治疗的自发性高血压大鼠（n = 8）红细胞内的游离镁水平，并将其与年龄匹配的Wistar - Kyoto大鼠（WKY）（n = 10）进行比较。与对照WKY相比，未经治疗的SHR细胞内游离镁水平显著降低（p < 0.01）。与未经治疗的SHR相比，地尔硫䓬成功的降压治疗增加了细胞内游离镁水平（p < 0.05）。此外，在所有组中均观察到细胞内游离镁水平与血压水平呈负相关（r = -0.48，p < 0.01，n = 25）。这些观察结果表明，细胞内镁代谢异常可能部分与SHR高血压的发生或维持有关。