Uribe S, Villalobos-Molina R, Devlin T M
Biochem Biophys Res Commun. 1987 Mar 30;143(3):1024-9. doi: 10.1016/0006-291x(87)90354-8.
Chemically synthesized oligomers (dimers, trimers and tetramers) of 15-dehydroprostaglandin B1 and 16,16'dimethyl-15-dehydroprostaglandin B1 (16,16'diMePGB1) are effective Ca2+ ionophores with isolated mitochondria and in artificial systems. The trimer of 16, 16'diMePGB1 mediated a dose dependent Ca2+ efflux from intact rat hepatocytes; at 9.2 microM oligomer, Ca2+ was released primarily from the mitochondrial pool but at higher concentrations from other cellular pools. The 16, 16'diMePGB1 trimer did not alter Ca2+ release mediated by epinephrine suggesting that the PGB1 oligomer interacts at a different site. The oligomer also caused an activation of phosphorylase similar to that mediated by epinephrine.
15-脱氢前列腺素B1和16,16'-二甲基-15-脱氢前列腺素B1（16,16'-二甲基PGB1）的化学合成低聚物（二聚体、三聚体和四聚体）在分离的线粒体和人工系统中是有效的钙离子载体。16,16'-二甲基PGB1的三聚体介导了完整大鼠肝细胞中剂量依赖性的钙离子外流；在9.2微摩尔低聚物时，钙离子主要从线粒体池中释放，但在更高浓度时从其他细胞池中释放。16,16'-二甲基PGB1三聚体不会改变由肾上腺素介导的钙离子释放，这表明PGB1低聚物在不同位点相互作用。该低聚物还引起了类似于肾上腺素介导的磷酸化酶激活。
