Devlin T M, Krupinski-Olsen R, Uribe S, Nelson G E
Biochem Biophys Res Commun. 1986 May 29;137(1):215-21. doi: 10.1016/0006-291x(86)91198-8.
Dimers, trimers and tetramers of 15-dehydro-PGB1 and of 16,16'-dimethyl-15-dehydro-PGB1 have been synthesized and their effect on mitochondrial function evaluated. The trimers and tetramers, and to a lesser extent the dimers, of both series, protected isolated mitochondria from the loss of phosphorylating capacity during in vitro incubation. The monomers were inactive. The trimers and tetramers inhibited between 40 and 50% the F1F0-ATPase of submitochondrial particles. All of the oligomers, but not the monomers, had Ca2+ ionophoretic activity with isolated mitochondria. These activities are qualitatively similar to that reported for the oligomeric mixture of 15-dehydro-PGB1, termed PGBX.
已合成了15-脱氢-PGB1和16,16'-二甲基-15-脱氢-PGB1的二聚体、三聚体和四聚体，并评估了它们对线粒体功能的影响。这两个系列的三聚体和四聚体，以及程度稍小的二聚体，在体外孵育期间保护分离的线粒体免于磷酸化能力的丧失。单体无活性。三聚体和四聚体抑制亚线粒体颗粒的F1F0-ATP酶40%至50%。所有的寡聚体，而非单体，对分离的线粒体具有Ca2+离子载体活性。这些活性在性质上与报道的称为PGBX的15-脱氢-PGB1寡聚体混合物相似。
