Department of Pediatrics, Division of Infectious Diseases, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Department of Anesthesiology, Critical Care and Pain Medicine, Division of Critical Care, Boston Children's Hospital, 300 Longwood Avenue, Bader 634, Boston, MA 02115, USA; Department of Anaesthesia and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Crit Care Clin. 2022 Jul;38(3):571-586. doi: 10.1016/j.ccc.2022.01.005. Epub 2022 Jan 10.
Severe complications related to COVID-19 occur infrequently in children and adolescents. these life-threatening complications are mainly acute respiratory failure from acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C). MIS-C is a postinfectious complication occurring approximately 3 to 6 weeks mostly after an asymptomatic or mild SARS-CoV-2 infection. For both types of complications, supportive ICU care is often required. For MIS-C critical illness, immunomodulation is prescribed to reverse hyperinflammation and its cardiac and other sequelae.
与 COVID-19 相关的严重并发症在儿童和青少年中很少发生。这些危及生命的并发症主要是由急性 COVID-19 引起的急性呼吸衰竭和儿童多系统炎症综合征 (MIS-C)。MIS-C 是一种感染后并发症，大约在无症状或轻度 SARS-CoV-2 感染后 3 至 6 周发生。对于这两种类型的并发症，通常需要 ICU 的支持性治疗。对于 MIS-C 危重症，会开具免疫调节药物来逆转过度炎症及其心脏和其他后遗症。
