National Horizons Centre, Teesside University, Darlington, DL1 1HG, UK; School of Health and Life Sciences, Teesside University, Middlesbrough, TS1 3BX, UK.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Trends Parasitol. 2022 Aug;38(8):642-659. doi: 10.1016/j.pt.2022.05.007. Epub 2022 Jun 3.
Microsporidian diversity is vast. There is a renewed drive to understand how microsporidian pathological, genomic, and ecological traits relate to their phylogeny. We comprehensively sample and phylogenetically analyse 125 microsporidian genera for which sequence data are available. Comparing these results with existing phylogenomic analyses, we suggest an updated taxonomic framework to replace the inconsistent clade numbering system, using informal taxonomic names: Glugeida (previously clades 5/3), Nosematida (4a), Enterocytozoonida (4b), Amblyosporida (3/5), Neopereziida (1), and Ovavesiculida (2). Cellular, parasitological, and ecological traits for 281 well-defined species are compared with identify clade-specific patterns across long-branch Microsporidia. We suggest that future taxonomic circumscriptions of Microsporidia should involve additional markers (SSU/ITS/LSU), and that a comprehensive suite of phenotypic and ecological traits help to predict broad microsporidian functional and lineage diversity.
微孢子虫的多样性非常丰富。目前人们重新燃起了对理解微孢子虫病理学、基因组学和生态学特征与其系统发育之间关系的兴趣。我们全面采样并对 125 个具有序列数据的微孢子虫属进行了系统发育分析。将这些结果与现有的系统基因组分析进行比较，我们建议使用非正式的分类学名称来更新分类框架，以取代不一致的进化枝编号系统：Glugeida（以前为 5/3 进化枝）、Nosematida（4a）、Enterocytozoonida（4b）、Amblyosporida（3/5）、Neopereziida（1）和 Ovavesiculida（2）。对 281 种定义明确的物种的细胞、寄生虫学和生态学特征进行了比较，以确定长枝微孢子虫中特定进化枝的模式。我们建议，未来微孢子虫的分类定义应涉及其他标记（SSU/ITS/LSU），并且全面的表型和生态特征有助于预测广泛的微孢子虫功能和谱系多样性。
