Vegner R E, Rituma I R, Chipens G I, Duplishcheva A P, Mysiakin E B
Bioorg Khim. 1987 Jan;13(1):122-4.
Structural similarity between Staphylococcus enterotoxin B and a thymus hormone, thymopoietin, has been revealed concerning thymopentin, one of active centres of thymopoietin. Fragments of enterotoxin B homologous to thymopoietin and their analogues were synthesized their immunological activity studied. Acetyl derivative of the fragment 225-229 of enterotoxin B increased infectional resistance and stimulated delayed type of hypersensitivity reaction.
已发现葡萄球菌肠毒素B与一种胸腺激素促胸腺生成素在促胸腺生成素的活性中心之一胸腺五肽方面存在结构相似性。合成了与促胸腺生成素同源的肠毒素B片段及其类似物,并研究了它们的免疫活性。肠毒素B 225 - 229片段的乙酰衍生物提高了抗感染能力并刺激了迟发型超敏反应。