Viamontes G I, Audhya T, Goldstein G
Cell Immunol. 1986 Jul;100(2):305-13. doi: 10.1016/0008-8749(86)90031-6.
Thymopoietin-containing cells in the thymus were identified immunohistochemically using murine antiserum generated by immunization with synthetic Cys-thymopoietin28-39 (Cys-TP28-39). human thymopoietin, This antiserum, previously shown to react with both bovine and human thymopoietin, gave reactivity restricted to cortical and medullary epithelial cells of bovine and human thymus. Monoclonal antibodies with reactivity restricted to native bovine thymopoietin did not react with tissue sections of bovine thymus; most likely the epitopes recognized by monoclonal antibodies are not expressed on the inactive precursor forms of thymopoietin within thymic epithelial cells.
使用通过用合成的半胱氨酸 - 胸腺生成素28 - 39（Cys - TP28 - 39）免疫产生的鼠抗血清，通过免疫组织化学方法在胸腺中鉴定了含胸腺生成素的细胞。这种抗血清先前已显示与牛和人胸腺生成素都有反应，其反应性仅限于牛和人胸腺的皮质和髓质上皮细胞。对天然牛胸腺生成素有反应性的单克隆抗体与牛胸腺组织切片无反应；很可能单克隆抗体识别的表位在胸腺上皮细胞内胸腺生成素的无活性前体形式上不表达。
