Youssif N, Ammon H P
Arzneimittelforschung. 1986 Dec;36(12):1717-20.
1-Amino-3,5-dimethyladamantane hydrochloride (memantine, D-145, Akatinol) and aminophylline were shown to increase the locomotor activity of mice in a dose-dependent manner; yet the effect of aminophylline took place and decreased faster than that of memantine. The ED25 for memantine was found to be 4 mg/kg; the moderate increase of locomotor activity caused by this dose of memantine was potentiated by aminophylline. The combination of both led to an over-additive immediate onset of effect and was longer lasting than that produced by memantine alone. An optimal potentiation of memantine effect was reached when it was combined with aminophylline in molar ratio of 1:2. The possible mechanism of this synergistic effect is discussed.
盐酸1-氨基-3,5-二甲基金刚烷（美金刚，D-145，阿卡替诺）和氨茶碱呈剂量依赖性地增加小鼠的运动活性；然而，氨茶碱的作用起效快且消退也比美金刚快。美金刚的半数有效量（ED25）为4毫克/千克；该剂量美金刚引起的运动活性适度增加可被氨茶碱增强。两者联用导致效应立即超相加，且持续时间比单独使用美金刚更长。当美金刚与氨茶碱以1:2的摩尔比联合使用时，可达到美金刚效应的最佳增强效果。文中讨论了这种协同效应的可能机制。
