Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Kwara State, Nigeria.
Kwara State Primary Healthcare Development Agency, Ilorin, Kwara State, Nigeria.
BMC Vet Res. 2022 Jun 7;18(1):214. doi: 10.1186/s12917-022-03331-3.
Antimicrobial resistance is a global public health crisis. However, there is a paucity of data on anti-protozoal resistance (APR), especially in animals. Hence, we assessed the knowledge of prudent antiprotozoal drug usage (APU) and resistance among animal health practitioners (AHPs) in Kwara State, Nigeria.A cross-sectional survey of 435 AHPs was performed in Kwara State from the 5th of March to the 31st of July 2020 using a structured and validated questionnaire. We used logistic regression analysis to identify socio-demographic factors that are associated with the satisfactory perception of prudent APU and good knowledge of APR among AHPs.Our findings showed that 80.2% (n = 349) of the AHPs in Kwara state had a good knowledge of APR with a mean knowledge score of 5.8 ± 1.2. In the same vein, 75.6% (n = 329) of the AHPs had a satisfactory perception of prudent APU with a mean score of 3.84 ± 1.21. Only 10.1% of the AHPs had observed treatment failures after the use of anti-protozoal drugs. Most of the AHPs (75.6%) believed that APR poses a significant threat to animal production and health globally. Logistic regression analysis showed that female AHPs were more likely (OR: 2.17; 95% CI: 0.91, 5.20; p < 0.005) to have better knowledge of APR than their male counterparts. AHPs with tertiary education were likely (OR: 2.77; 95% CI: 0.96, 4.99; p < 0.05) to be more knowledgeable about APR and have satisfactory perceptions of APU (OR: 1.57; 95% CI: 1.16, 2.99; p = 0.07) respectively. Finally, veterinarians were 3.76 times (95% CI:1.26, 9.25; p < 0.001) more likely to have good knowledge of APR and better perceptions of APU (OR: 3.28; 95% CI: 1.89, 5.68; p < 0.001) than other AHPs respectively.To control antimicrobial resistance, continuous training of AHPs especially para-veterinary officers is essential to update their knowledge on prudent antimicrobial usage and prevent the emergence of resistant protozoan parasites.
抗微生物药物耐药性是全球公共卫生危机。然而，关于抗原生动物药物耐药性（APR）的数据很少，特别是在动物中。因此，我们评估了尼日利亚克瓦拉州动物保健从业者（AHPs）对抗原生动物药物合理使用（APU）和耐药性的认识。
我们于 2020 年 3 月 5 日至 7 月 31 日在克瓦拉州对 435 名 AHPs 进行了横断面调查，使用了结构化和经过验证的问卷。我们使用逻辑回归分析来确定与 AHPs 对抗原生动物药物合理使用的满意度和 APR 知识良好相关的社会人口统计学因素。
我们的研究结果表明，克瓦拉州 80.2%（n=349）的 AHPs 对 APR 有很好的了解，平均知识得分为 5.8±1.2。同样，75.6%（n=329）的 AHPs 对对抗原生动物药物合理使用有满意的认识，平均得分为 3.84±1.21。只有 10.1%的 AHPs 在使用抗原生动物药物后观察到治疗失败。大多数 AHPs（75.6%）认为 APR 对全球动物生产和健康构成重大威胁。逻辑回归分析表明，女性 AHPs 比男性 AHPs 更有可能（OR：2.17；95%CI：0.91，5.20；p<0.005）对 APR 有更好的了解。接受过高等教育的 AHPs 更有可能（OR：2.77；95%CI：0.96，4.99；p<0.05）了解 APR，并对 APU 有满意的认识（OR：1.57；95%CI：1.16，2.99；p=0.07）。最后，兽医比其他 AHPs 更有可能（OR：3.76；95%CI：1.26，9.25；p<0.001）更好地了解 APR 和 APU（OR：3.28；95%CI：1.89，5.68；p<0.001）。
为了控制抗微生物药物耐药性，必须对 AHPs 特别是准兽医进行持续培训，以更新他们对抗微生物药物合理使用的知识，防止出现耐药原生动物寄生虫。
