Department of Neurology, Shandong Provincial Corps Hospital of Chinese People's Armed Police Forces, Shandong, PR China.
Department of Neurology, the 960th Hospital of People's Liberation Army, Jinan, Shandong, PR China.
Pak J Pharm Sci. 2022 Mar;35(2(Special)):613-618.
To assess cerebral hemodynamic changes by transcranial doppler ultrasound in patients with acute cerebral infarction before and after treatment with butylphthalide, A total of 90 patients with acute cerebral infarction admitted to our hospital from January 2019 to January 2020 were selected and equally divided into the control group and the experimental group according to the order of admission. The control group was treated with conventional treatment, while the experimental group was additionally given butylphthalide drug treatment. The experimental group obtained better hemodynamic indexes as compared with the control group (P<0.05). The experimental group yielded a notably higher total clinical effective rate after treatment in contrast with the control group (P<0.05). After treatment, the serum indexes of the experimental group were evidently lower than those of the control group (P<0.05). After treatment, a remarkably lower NIHSS score of the experimental group than the control group was observed (P<0.05). The BI index score of the experimental group after treatment was considerably higher than that of the control group (P<0.05). After treatment, the MMSE score in the experimental group was significantly higher than it was in the control group (P<0.05). The treatment of butylphthalide in patients with acute cerebral infarction can effectively improve the clinical symptoms of the patients and the cerebral hemodynamics of the patients tested by TCD found that this treatment yields an excellent therapeutic effect and is worthy of promotion and application.
采用经颅多普勒超声评估急性脑梗死患者在使用丁苯酞治疗前后的脑血流动力学变化。选取我院 2019 年 1 月至 2020 年 1 月收治的急性脑梗死患者 90 例,按入院顺序分为对照组和实验组,各 45 例。对照组采用常规治疗,实验组在常规治疗基础上加用丁苯酞药物治疗。实验组的血流动力学指标优于对照组(P<0.05)。实验组治疗后的总临床有效率明显高于对照组(P<0.05)。实验组治疗后的血清指标明显低于对照组(P<0.05)。实验组治疗后的 NIHSS 评分明显低于对照组(P<0.05)。实验组治疗后的 BI 指数评分明显高于对照组(P<0.05)。实验组治疗后的 MMSE 评分明显高于对照组(P<0.05)。丁苯酞治疗急性脑梗死患者,可有效改善患者的临床症状,TCD 检测患者脑血流动力学变化发现,该治疗方法疗效显著,值得推广应用。