Department of Biochemistry, Baqai Medical University, Karachi, Pakistan.
Research Department, Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan.
Pak J Pharm Sci. 2022 Mar;35(2(Special)):679-683.
The purpose of this study is to evaluate quality of life, the gonadotropins and estrogen levels in type 1 diabetic adolescent females. This cross-sectional study was conducted at Baqai Institute of Diabetology and Endocrinology (BIDE). The Diabetes quality of life for youth questionnaire (DQOLY) was used to evaluate quality of life. FSH was found to be significantly lower in Type 1 Diabetes. HbA1c had a significant inverse moderate correlation with FSH(-0.300*).In Type 1 Diabetes, FSH had a positive moderate correlation with LH(0.415*), (P-value<0.05). LH and estradiol levels were almost similar in both groups. Overall mean percentage score of DQOLY questionnaire for Type 1 Diabetes was 26.94±1.36. Low QOL score was observed on the basis of impact on activities. Adolescent females with Type 1 Diabetes were found to be shorter and underweight than non-diabetic adolescent females. Lower height and weight of the diabetes as compared to controls cannot be attributed to only metabolic control, suggesting other mechanisms for short stature. Control on metabolism has always been the target for diabetes treatment for ensuring the improved prognosis of disease but also for the quality of life in Type 1 diabetes.
本研究旨在评估 1 型糖尿病青少年女性的生活质量、促性腺激素和雌激素水平。这项横断面研究在拜盖伊糖尿病和内分泌研究所（BIDE）进行。使用青少年糖尿病生活质量问卷（DQOLY）评估生活质量。发现 1 型糖尿病患者的 FSH 明显降低。HbA1c 与 FSH 呈显著负中等相关（-0.300*）。在 1 型糖尿病中，FSH 与 LH 呈正中等相关（0.415*），（P 值<0.05）。两组的 LH 和雌二醇水平几乎相似。1 型糖尿病的 DQOLY 问卷总体平均百分比评分 26.94±1.36。根据对活动的影响，发现 1 型糖尿病患者的 QOL 评分较低。与非糖尿病青少年女性相比，1 型糖尿病的青少年女性身材更矮、体重更轻。与对照组相比，糖尿病患者的身高和体重较低不能仅归因于代谢控制，这表明存在导致身材矮小的其他机制。代谢控制一直是糖尿病治疗的目标，以确保改善疾病预后，同时提高 1 型糖尿病患者的生活质量。
